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TitleAffinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 15960-15965, Year 2011
Publish dateMay 20, 2011 (structure data deposition date)
AuthorsWang, X.X. / Li, Y. / Yin, Y. / Mo, M. / Wang, Q. / Gao, W. / Wang, L. / Mariuzza, R.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:21900604
MethodsX-ray diffraction
Resolution2.1 - 2.4 Å
Structure data

PDB-3s4s:
Crystal structure of CD4 mutant bound to HLA-DR1
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3s5l:
Crystal structure of CD4 mutant bound to HLA-DR1
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • influenza a virus
KeywordsIMMUNE SYSTEM / protein-protein complex / co-receptor

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