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| Title | TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors. |
|---|---|
| Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 55, Page 5723-5731, Year 2011 |
| Publish date | Mar 17, 2011 (structure data deposition date) |
Authors | Dierynck, I. / Van Marck, H. / Van Ginderen, M. / Jonckers, T.H. / Nalam, M.N. / Schiffer, C.A. / Raoof, A. / Kraus, G. / Picchio, G. |
External links | Antimicrob. Agents Chemother. / PubMed:21896904 |
| Methods | X-ray diffraction |
| Resolution | 1.9 Å |
| Structure data | ![]() PDB-3r4b: |
| Chemicals | ![]() ChemComp-74T: ![]() ChemComp-PO4: ![]() ChemComp-HOH: |
| Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / drug resistance / drug design / protease inhibitors / AIDS / aspartyl protease / HYDROLASE-HYDROLASE INHIBITOR complex |
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human immunodeficiency virus 1
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