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| Title | 2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation. |
|---|---|
| Journal, issue, pages | J. Biol. Chem., Vol. 286, Page 37578-, Year 2011 |
| Publish date | Jun 21, 2011 (structure data deposition date) |
Authors | Tiden, A.K. / Sjogren, T. / Svensson, M. / Bernlind, A. / Senthilmohan, R. / Auchere, F. / Norman, H. / Markgren, P.O. / Gustavsson, S. / Schmidt, S. ...Tiden, A.K. / Sjogren, T. / Svensson, M. / Bernlind, A. / Senthilmohan, R. / Auchere, F. / Norman, H. / Markgren, P.O. / Gustavsson, S. / Schmidt, S. / Lundquist, S. / Forbes, L.V. / Magon, N.J. / Paton, L.N. / Jameson, G.N. / Eriksson, H. / Kettle, A.J. |
External links | J. Biol. Chem. / PubMed:21880720 |
| Methods | X-ray diffraction |
| Resolution | 2.3 - 2.6 Å |
| Structure data | ![]() PDB-3zs0: ![]() PDB-3zs1: |
| Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-ZS0: ![]() ChemComp-HEM: ![]() ChemComp-NAG: ![]() ChemComp-CA: ![]() ChemComp-CL: ![]() ChemComp-ACT: ![]() ChemComp-HOH: ![]() ChemComp-PVW: |
| Source |
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Keywords | OXIDOREDUCTASE / ENZYME INACTIVATION / INFLAMMATION / NEUTROPHIL / REACTIVE OXYGEN SPECIES (ROS) / HYPOCHLOROUS ACID |
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homo sapiens (human)
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