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Structure paper

TitleThe higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 412, Page 737-742, Year 2011
Publish dateJun 30, 2011 (structure data deposition date)
AuthorsWang, Y. / Liu, Z. / Brunzelle, J.S. / Kovari, I.A. / Dewdney, T.G. / Reiter, S.J. / Kovari, L.C.
External linksBiochem. Biophys. Res. Commun. / PubMed:21871444
MethodsX-ray diffraction
Resolution1.24 - 2.87 Å
Structure data

PDB-3so9:
Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

PDB-3spk:
Tipranavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

Chemicals

ChemComp-017:
(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE / medication, antiretroviral*YM

ChemComp-HOH:
WATER

ChemComp-TPV:
N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE / protease inhibitor*YM

Source
  • human immunodeficiency virus 1
  • human immunodeficiency virus type 1
KeywordsHYDORLASE/HYDORLASE INHIBITOR / multi-drug resistance / HIV-1 protease / darunavir / protease inhibitor / HYDORLASE-HYDORLASE INHIBITOR complex / tipranavir / multi-drug resistant HIV-1 protease

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