+Search query
-Structure paper
Title | Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 5521-5527, Year 2011 |
Publish date | May 3, 2011 (structure data deposition date) |
Authors | Bowers, S. / Truong, A.P. / Jeffrey Neitz, R. / Hom, R.K. / Sealy, J.M. / Probst, G.D. / Quincy, D. / Peterson, B. / Chan, W. / Galemmo, R.A. ...Bowers, S. / Truong, A.P. / Jeffrey Neitz, R. / Hom, R.K. / Sealy, J.M. / Probst, G.D. / Quincy, D. / Peterson, B. / Chan, W. / Galemmo, R.A. / Konradi, A.W. / Sham, H.L. / Toth, G. / Pan, H. / Lin, M. / Yao, N. / Artis, D.R. / Zhang, H. / Chen, L. / Dryer, M. / Samant, B. / Zmolek, W. / Wong, K. / Lorentzen, C. / Goldbach, E. / Tonn, G. / Quinn, K.P. / Sauer, J.M. / Wright, S. / Powell, K. / Ruslim, L. / Ren, Z. / Bard, F. / Yednock, T.A. / Griswold-Prenner, I. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21813278 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-3rtp: |
Chemicals | ChemComp-34I: ChemComp-HOH: |
Source |
|
Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / JNK inhibitors / pharmacokinetic properties / neurodegeneration / TRANSFERASE-TRANSFERASE INHIBITOR complex |