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TitleIntroducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 50, Page 8714-8717, Year 2011
Publish dateMar 20, 2014 (structure data deposition date)
AuthorsKnappe, T.A. / Manzenrieder, F. / Mas-Moruno, C. / Linne, U. / Sasse, F. / Kessler, H. / Xie, X. / Marahiel, M.A.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:21812076
MethodsNMR (solution)
Structure data

PDB-2mmw:
LASSO PEPTIDE BASED INTEGRIN INHIBITOR: MICROCIN J25 VARIANT WITH RGD SUBSTITUTION of GLY12-ILE13-GLY14
Method: SOLUTION NMR

Source
  • escherichia coli (E. coli)
KeywordsANTIBIOTIC / LASSO PEPTIDE / MICROCIN J25 / EPITOPE GRAFTING / PEPTIDE SCAFFOLD / INTEGRIN INHIBITOR / ANGIOGENESIS / ANTIMICROBIAL PROTEIN / CELL ADHESION INHIBITOR

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