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Structure paper

TitlePyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 5533-5537, Year 2011
Publish dateJun 22, 2011 (structure data deposition date)
AuthorsWenglowsky, S. / Ahrendt, K.A. / Buckmelter, A.J. / Feng, B. / Gloor, S.L. / Gradl, S. / Grina, J. / Hansen, J.D. / Laird, E.R. / Lunghofer, P. ...Wenglowsky, S. / Ahrendt, K.A. / Buckmelter, A.J. / Feng, B. / Gloor, S.L. / Gradl, S. / Grina, J. / Hansen, J.D. / Laird, E.R. / Lunghofer, P. / Mathieu, S. / Moreno, D. / Newhouse, B. / Ren, L. / Risom, T. / Rudolph, J. / Seo, J. / Sturgis, H.L. / Voegtli, W.C. / Wen, Z.
External linksBioorg. Med. Chem. Lett. / PubMed:21802293
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-3skc:
Human B-Raf Kinase in Complex with an Amide Linked Pyrazolopyridine Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-BR2:
2,6-difluoro-N-[(5S)-3-methoxy-5H-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide

Source
  • homo sapiens (human)
KeywordsTransferase/Transferase Inhibitor / Kinase / ATP-competitive inhibitor / Transferase / Ras / Mek / C-Raf / Transferase-Transferase Inhibitor complex

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