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-Structure paper
Title | Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure. |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 5890-5901, Year 2011 |
Publish date | Jul 8, 2011 (structure data deposition date) |
Authors | Ghosh, A.K. / Chapsal, B.D. / Parham, G.L. / Steffey, M. / Agniswamy, J. / Wang, Y.F. / Amano, M. / Weber, I.T. / Mitsuya, H. |
External links | J. Med. Chem. / PubMed:21800876 |
Methods | X-ray diffraction |
Resolution | 1.45 Å |
Structure data | PDB-3st5: |
Chemicals | ChemComp-CL: ChemComp-G89: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / aspartic acid protease / HIV-1 protease inhibitor GRL-0489A / C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-ligands / HYDROLASE-HYDROLASE INHIBITOR complex |