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TitleProtein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page E542-E549, Year 2011
Publish dateMay 25, 2010 (structure data deposition date)
AuthorsCardinale, D. / Guaitoli, G. / Tondi, D. / Luciani, R. / Henrich, S. / Salo-Ahen, O.M. / Ferrari, S. / Marverti, G. / Guerrieri, D. / Ligabue, A. ...Cardinale, D. / Guaitoli, G. / Tondi, D. / Luciani, R. / Henrich, S. / Salo-Ahen, O.M. / Ferrari, S. / Marverti, G. / Guerrieri, D. / Ligabue, A. / Frassineti, C. / Pozzi, C. / Mangani, S. / Fessas, D. / Guerrini, R. / Ponterini, G. / Wade, R.C. / Costi, M.P.
External linksProc. Natl. Acad. Sci. USA / PubMed:21795601
MethodsX-ray diffraction
Resolution2.26 - 2.27 Å
Structure data

PDB-3n5e:
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-3n5g:
Crystal Structure of histidine-tagged human thymidylate synthase
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / peptide inhibitor / protein-peptide complex / interface inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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