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TitleCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells
Journal, issue, pagesGenes Cancer, Vol. 1, Page 369-380, Year 2010
Publish dateFeb 8, 2010 (structure data deposition date)
AuthorsBettayeb, K. / Baunbak, D. / Delehouze, C. / Loaec, N. / Hole, A.J. / Baumli, S. / Endicott, J.A. / Douc-Rasy, S. / Benard, J. / Oumata, N. ...Bettayeb, K. / Baunbak, D. / Delehouze, C. / Loaec, N. / Hole, A.J. / Baumli, S. / Endicott, J.A. / Douc-Rasy, S. / Benard, J. / Oumata, N. / Galons, H. / Meijer, L.
External linksGenes Cancer / PubMed:21779453
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-3lq5:
Structure of CDK9/CyclinT in complex with S-CR8
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-SLQ:
(2S)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION/INHIBITOR / TRANSCRIPTIONAL CDK-CYCLIN COMPLEX / PHOSPHORYLATED / ATP-BINDING / KINASE / NUCLEOTIDE-BINDING / NUCLEUS / PHOSPHOPROTEIN / SERINE/THREONINE-PROTEIN KINASE / TRANSCRIPTION REGULATION / TRANSFERASE / CELL CYCLE / CELL DIVISION / HOST-VIRUS INTERACTION / TRANSCRIPTION-INHIBITOR complex

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