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Structure paper

TitleStructural basis of type II topoisomerase inhibition by the anticancer drug etoposide
Journal, issue, pagesScience, Vol. 333, Page 459-462, Year 2011
Publish dateMar 1, 2011 (structure data deposition date)
AuthorsWu, C.C. / Li, T.K. / Farh, L. / Lin, L.Y. / Lin, T.S. / Yu, Y.J. / Yen, T.J. / Chiang, C.W. / Chan, N.L.
External linksScience / PubMed:21778401
MethodsX-ray diffraction
Resolution2.162 Å
Structure data

PDB-3qx3:
Human topoisomerase IIbeta in complex with DNA and etoposide
Method: X-RAY DIFFRACTION / Resolution: 2.162 Å

Chemicals

ChemComp-EVP:
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol / medication, chemotherapy*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsISOMERASE/DNA/ISOMERASE INHIBITOR / TOPRIM domain / winged-helix domain / coiled-coil domain / DNA binding and cleavage / nucleus / ISOMERASE-DNA-ISOMERASE INHIBITOR complex

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