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TitleFeatures of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise with Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90.
Journal, issue, pagesFaseb J., Vol. 25, Page 3828-, Year 2011
Publish dateApr 12, 2011 (structure data deposition date)
AuthorsMillson, S.H. / Chua, C. / Roe, S.M. / Polier, S. / Solovieva, S. / Pearl, L.H. / Sim, T. / Prodromou, C. / Piper, P.W.
External linksFaseb J. / PubMed:21778327
MethodsX-ray diffraction
Resolution1.956 - 2.37 Å
Structure data

PDB-2yga:
E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-2yge:
E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin
Method: X-RAY DIFFRACTION / Resolution: 1.956 Å

PDB-2ygf:
L89V, L93I and V136M Mutant of N-Term HSP90 complexed with Geldanamycin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-GDM:
GELDANAMYCIN / antitumor, antibiotic*YM

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsCHAPERONE

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