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TitleSerendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Journal, issue, pagesNat. Chem. Biol., Vol. 7, Page 595-601, Year 2011
Publish dateApr 27, 2011 (structure data deposition date)
AuthorsLiu, F. / Park, J.E. / Qian, W.J. / Lim, D. / Graber, M. / Berg, T. / Yaffe, M.B. / Lee, K.S. / Burke, T.R.
External linksNat. Chem. Biol. / PubMed:21765407
MethodsX-ray diffraction
Resolution1.55 Å
Structure data

PDB-3rq7:
Polo-like kinase 1 Polo box domain in complex with a C6H5(CH2)8-derivatized peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / phosphopeptide binding domain / TRANSFERASE-TRANSFERASE INHIBITOR complex

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