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-Structure paper
Title | Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 19, Page 4953-4970, Year 2011 |
Publish date | Sep 1, 2010 (structure data deposition date) |
![]() | Banno, Y. / Miyamoto, Y. / Sasaki, M. / Oi, S. / Asakawa, T. / Kataoka, O. / Takeuchi, K. / Suzuki, N. / Ikedo, K. / Kosaka, T. ...Banno, Y. / Miyamoto, Y. / Sasaki, M. / Oi, S. / Asakawa, T. / Kataoka, O. / Takeuchi, K. / Suzuki, N. / Ikedo, K. / Kosaka, T. / Tsubotani, S. / Tani, A. / Funami, M. / Tawada, M. / Yamamoto, Y. / Aertgeerts, K. / Yano, J. / Maezaki, H. |
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Methods | X-ray diffraction |
Resolution | 2.72 Å |
Structure data | ![]() PDB-3opm: |
Chemicals | ![]() ChemComp-LUI: ![]() ChemComp-NAG: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / protease and 8-bladed beta-propeller domain / Aminopeptidase / Cell membrane / Glycoprotein / Hydrolase / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane / SIGNALING PROTEIN / HYDROLASE-HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex |