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Structure paper

TitleModular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 18, Page 886-, Year 2011
Publish dateApr 19, 2011 (structure data deposition date)
AuthorsMalinauskas, T. / Aricescu, A.R. / Lu, W. / Siebold, C. / Jones, E.Y.
External linksNat. Struct. Mol. Biol. / PubMed:21743455
MethodsX-ray diffraction
Resolution1.85 - 3.951 Å
Structure data

PDB-2ygn:
WIF domain of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2ygo:
WIF domain-EGF-like domain 1 of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2ygp:
WIF domain-EGF-like domain 1 Met77Trp of human Wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine
Method: X-RAY DIFFRACTION / Resolution: 2.222 Å

PDB-2ygq:
WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
Method: X-RAY DIFFRACTION / Resolution: 3.951 Å

Chemicals

ChemComp-PCF:
1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-SPD:
SPERMIDINE

ChemComp-FUC:
alpha-L-fucopyranose

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / WNT SIGNALING PATHWAY / WNT ANTAGONIST / MORPHOGEN / CANCER / GLYCOSAMINOGLYCAN

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