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Structure paper

TitleMolecular insights into DNA polymerase deterrents for ribonucleotide insertion.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 31650-31660, Year 2011
Publish dateApr 11, 2011 (structure data deposition date)
AuthorsCavanaugh, N.A. / Beard, W.A. / Batra, V.K. / Perera, L. / Pedersen, L.G. / Wilson, S.H.
External linksJ. Biol. Chem. / PubMed:21733843
MethodsX-ray diffraction
Resolution1.918 - 2.096 Å
Structure data

PDB-3rh4:
DNA Polymerase Beta with a dideoxy-terminated primer with an incoming ribonucleotide (rCTP)
Method: X-RAY DIFFRACTION / Resolution: 1.918 Å

PDB-3rh5:
DNA Polymerase Beta Mutant (Y271) with a dideoxy-terminated primer with an incoming deoxynucleotide (dCTP)
Method: X-RAY DIFFRACTION / Resolution: 2.096 Å

PDB-3rh6:
DNA Polymerase Beta Mutant (Y271) with a dideoxy-terminated primer with an incoming ribonucleotide (rCTP)
Method: X-RAY DIFFRACTION / Resolution: 2.048 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-CTP:
CYTIDINE-5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / DNA Polymerase / ribonucleotide insertion / rCTP / TRANSFERASE-DNA complex / DNA Polymerase Beta mutant / nucleotide transferase / dCTP / polymerase beta

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