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Structure paper

TitleThrombin-aptamer recognition: a revealed ambiguity.
Journal, issue, pagesNucleic Acids Res., Vol. 39, Page 7858-7867, Year 2011
Publish dateFeb 3, 2011 (structure data deposition date)
AuthorsRusso Krauss, I. / Merlino, A. / Giancola, C. / Randazzo, A. / Mazzarella, L. / Sica, F.
External linksNucleic Acids Res. / PubMed:21715374
MethodsX-ray diffraction
Resolution2.14 Å
Structure data

PDB-3qlp:
X-ray structure of the complex between human alpha thrombin and a modified thrombin binding aptamer (mTBA)
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-0G6:
D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NA:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR/DNA / PROTEIN-DNA COMPLEX / SERINE PROTEASE / BLOOD COAGULATION / aptamer / serine protease fold / HYDROLASE-HYDROLASE INHIBITOR-DNA complex

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