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TitleA Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients.
Journal, issue, pagesCancer Res., Vol. 71, Page 5255-5264, Year 2011
Publish dateFeb 22, 2011 (structure data deposition date)
AuthorsTiedt, R. / Degenkolbe, E. / Furet, P. / Appleton, B.A. / Wagner, S. / Schoepfer, J. / Buck, E. / Ruddy, D.A. / Monahan, J.E. / Jones, M.D. ...Tiedt, R. / Degenkolbe, E. / Furet, P. / Appleton, B.A. / Wagner, S. / Schoepfer, J. / Buck, E. / Ruddy, D.A. / Monahan, J.E. / Jones, M.D. / Blank, J. / Haasen, D. / Drueckes, P. / Wartmann, M. / McCarthy, C. / Sellers, W.R. / Hofmann, F.
External linksCancer Res. / PubMed:21697284
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3qti:
c-Met Kinase in Complex with NVP-BVU972
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-3QT:
6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / kinase / TRANSERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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