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TitleCrystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.
Journal, issue, pagesJ. Struct. Biol., Vol. 176, Page 52-59, Year 2011
Publish dateMay 14, 2010 (structure data deposition date)
AuthorsCody, V. / Pace, J. / Piraino, J. / Queener, S.F.
External linksJ. Struct. Biol. / PubMed:21684339
MethodsX-ray diffraction
Resolution1.53 - 1.92 Å
Structure data

PDB-3n0h:
hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-3s3v:
human dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim
Method: X-RAY DIFFRACTION / Resolution: 1.53 Å

Chemicals

ChemComp-TOP:
TRIMETHOPRIM / antibiotic*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / double mutant human dihydrofolate reductase trimethoprim / OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / novel second binding site / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

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