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-Structure paper
Title | Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. |
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Journal, issue, pages | J. Struct. Biol., Vol. 176, Page 52-59, Year 2011 |
Publish date | May 14, 2010 (structure data deposition date) |
![]() | Cody, V. / Pace, J. / Piraino, J. / Queener, S.F. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.53 - 1.92 Å |
Structure data | ![]() PDB-3n0h: ![]() PDB-3s3v: |
Chemicals | ![]() ChemComp-TOP: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / double mutant human dihydrofolate reductase trimethoprim / OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / novel second binding site / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |