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TitleIdentification of Ustilago maydis Aurora kinase as a novel antifungal target.
Journal, issue, pagesAcs Chem. Biol., Vol. 6, Page 926-933, Year 2011
Publish dateJan 13, 2011 (structure data deposition date)
AuthorsTueckmantel, S. / Greul, J.N. / Janning, P. / Brockmeyer, A. / Gruetter, C. / Simard, J.R. / Gutbrod, O. / Beck, M.E. / Tietjen, K. / Rauh, D. / Schreier, P.H.
External linksAcs Chem. Biol. / PubMed:21671622
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-3qbn:
Structure of Human Aurora A in Complex with a diaminopyrimidine
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-E9Z:
5-chloro-N~4~-cyclopropyl-N~2~-[4-(2-methoxyethoxy)phenyl]pyrimidine-2,4-diamine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Kinase Domain / Diaminopyrimidine / TRANSFERASE-TRANSFERASE INHIBITOR complex

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