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Structure paper

TitleMolecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
Journal, issue, pagesPLoS ONE, Vol. 6, Page e20033-e20033, Year 2011
Publish dateApr 4, 2011 (structure data deposition date)
AuthorsBreuer, S. / Schievink, S.I. / Schulte, A. / Blankenfeldt, W. / Fackler, O.T. / Geyer, M.
External linksPLoS ONE / PubMed:21625496
MethodsX-ray diffraction
Resolution2 - 3.45 Å
Structure data

PDB-3rea:
HIV-1 Nef protein in complex with engineered Hck-SH3 domain
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3reb:
HIV-1 Nef protein in complex with engineered Hck-SH3 domain
Method: X-RAY DIFFRACTION / Resolution: 3.45 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • hiv-1 m:b_arv2/sf2 (virus)
  • homo sapiens (human)
KeywordsPROTEIN BINDING / HIV-1 Nef / SH3 domain binding / signaling / Hck SH3 domain

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