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TitleA Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-{beta} Production in Vivo.
Journal, issue, pagesSci Transl Med, Vol. 3, Page 84ra43-84ra43, Year 2011
Publish dateMar 10, 2011 (structure data deposition date)
AuthorsAtwal, J.K. / Chen, Y. / Chiu, C. / Mortensen, D.L. / Meilandt, W.J. / Liu, Y. / Heise, C.E. / Hoyte, K. / Luk, W. / Lu, Y. ...Atwal, J.K. / Chen, Y. / Chiu, C. / Mortensen, D.L. / Meilandt, W.J. / Liu, Y. / Heise, C.E. / Hoyte, K. / Luk, W. / Lu, Y. / Peng, K. / Wu, P. / Rouge, L. / Zhang, Y. / Lazarus, R.A. / Scearce-Levie, K. / Wang, W. / Wu, Y. / Tessier-Lavigne, M. / Watts, R.J.
External linksSci Transl Med / PubMed:21613622
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-3r1g:
Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Aspartal protease

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