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TitleNovel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
Journal, issue, pagesChemmedchem, Vol. 6, Page 1351-1356, Year 2011
Publish dateMay 11, 2010 (structure data deposition date)
AuthorsMirkovic, B. / Renko, M. / Turk, S. / Sosic, I. / Jevnikar, Z. / Obermajer, N. / Turk, D. / Gobec, S. / Kos, J.
External linksChemmedchem / PubMed:21598397
MethodsX-ray diffraction
Resolution2.11 Å
Structure data

PDB-3ai8:
Cathepsin B in complex with the nitroxoline
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

Chemicals

ChemComp-HNQ:
5-nitroquinolin-8-ol / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / cathepsin B / reversible inhibitor / Nitroxoline / 8-Hydroxy-5-nitroquinoline / HYDROLASE-HYDROLASE INHIBITOR complex

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