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Structure paper

TitleCrystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor.
Journal, issue, pagesPlos One, Vol. 6, Page e19589-e19589, Year 2011
Publish dateDec 20, 2010 (structure data deposition date)
AuthorsFong, D.H. / Xiong, B. / Hwang, J. / Berghuis, A.M.
External linksPlos One / PubMed:21573013
MethodsX-ray diffraction
Resolution2.1501 - 2.9 Å
Structure data

PDB-3q2j:
Crystal Structure of 3',5"-Aminoglycoside Phosphotransferase Type IIIa Protein Kinase Inhibitor CKI-7 Complex
Method: X-RAY DIFFRACTION / Resolution: 2.1501 Å

PDB-3q2m:
Crystal Structure of Spectinomycin Phosphotransferase, APH(9)-Ia, Protein Kinase Inhibitor CKI-7 Complex
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-CKI:
N-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE

ChemComp-HOH:
WATER

ChemComp-NI:
NICKEL (II) ION

Source
  • enterococcus faecalis (bacteria)
  • legionella pneumophila 130b (bacteria)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Ser/Thr/Tyr protein kinase / kinase / phosphorylation / TRANSFERASE-TRANSFERASE INHIBITOR complex / phosphotransferase / cytosol

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