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TitleChemogenetic analysis of human protein methyltransferases.
Journal, issue, pagesChem. Biol. Drug Des., Vol. 78, Page 199-210, Year 2011
Publish dateFeb 11, 2011 (structure data deposition date)
AuthorsRichon, V.M. / Johnston, D. / Sneeringer, C.J. / Jin, L. / Majer, C.R. / Elliston, K. / Jerva, L.F. / Scott, M.P. / Copeland, R.A.
External linksChem. Biol. Drug Des. / PubMed:21564555
MethodsX-ray diffraction
Resolution2.1 - 2.3 Å
Structure data

PDB-3qow:
DOT1L Structure in complex with SAM
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3qox:
DOT1L structure in complex with SAH
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / H3K79 methylation

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