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TitleDiscovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-gamma.
Journal, issue, pagesJ. Med. Chem., Vol. 54, Page 4219-4233, Year 2011
Publish dateMar 23, 2011 (structure data deposition date)
AuthorsCasimiro-Garcia, A. / Filzen, G.F. / Flynn, D. / Bigge, C.F. / Chen, J. / Davis, J.A. / Dudley, D.A. / Edmunds, J.J. / Esmaeil, N. / Geyer, A. ...Casimiro-Garcia, A. / Filzen, G.F. / Flynn, D. / Bigge, C.F. / Chen, J. / Davis, J.A. / Dudley, D.A. / Edmunds, J.J. / Esmaeil, N. / Geyer, A. / Heemstra, R.J. / Jalaie, M. / Ohren, J.F. / Ostroski, R. / Ellis, T. / Schaum, R.P. / Stoner, C.
External linksJ. Med. Chem. / PubMed:21557540
MethodsX-ray diffraction
Resolution2.41 Å
Structure data

PDB-3r8a:
X-ray crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a compound with dual PPAR gamma agonism and Angiotensin II Type I receptor antagonism activity
Method: X-RAY DIFFRACTION / Resolution: 2.41 Å

Chemicals

ChemComp-HIG:
2-ethyl-5,7-dimethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3H-imidazo[4,5-b]pyridine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsNUCLEAR PROTEIN / Nuclear Hormone Activator / Angiotensin II Type I Receptor Antagonist / Ligand Bound Structure / Diabetes mellitus / Metabolic Syndrome / Obesity

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