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TitleQuinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 3358-3361, Year 2011
Publish dateMar 23, 2011 (structure data deposition date)
AuthorsKoller, M. / Lingenhoehl, K. / Schmutz, M. / Vranesic, I.T. / Kallen, J. / Auberson, Y.P. / Carcache, D.A. / Mattes, H. / Ofner, S. / Orain, D. / Urwyler, S.
External linksBioorg. Med. Chem. Lett. / PubMed:21531559
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3r7x:
Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-QSN:
N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / ion channel / ionic channel / postsynaptic membrane / transmembrane

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