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Structure paper

TitleAn induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity.
Journal, issue, pagesEmbo J., Vol. 30, Page 2167-2176, Year 2011
Publish dateDec 15, 2010 (structure data deposition date)
AuthorsPetty, T.J. / Emamzadah, S. / Costantino, L. / Petkova, I. / Stavridi, E.S. / Saven, J.G. / Vauthey, E. / Halazonetis, T.D.
External linksEmbo J. / PubMed:21522129
MethodsX-ray diffraction
Resolution2.1 - 3.2 Å
Structure data

PDB-3q01:
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3q05:
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3q06:
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / beta sandwich / multidomain / oligomerization / TP53 / p53 / tumor suppressor / dimer / DNA binding / ANTITUMOR PROTEIN/DNA / tetramer / ANTITUMOR PROTEIN-DNA complex / CELL CYCLE/DNA / CELL CYCLE-DNA complex

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