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TitleIdentification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 20625-20636, Year 2011
Publish dateNov 30, 2009 (structure data deposition date)
AuthorsHajicek, N. / Kukimoto-Niino, M. / Mishima-Tsumagari, C. / Chow, C.R. / Shirouzu, M. / Terada, T. / Patel, M. / Yokoyama, S. / Kozasa, T.
External linksJ. Biol. Chem. / PubMed:21507947
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-3ab3:
Crystal structure of p115RhoGEF RGS domain in complex with G alpha 13
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-ALF:
TETRAFLUOROALUMINATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN/MEMBRANE PROTEIN / SIGNAL TRANSDUCTION / PROTEIN COMPLEX / GTP-BINDING / MEMBRANE / TRANSDUCER / Lipoprotein / Nucleotide-binding / Palmitate / Phosphoprotein / GTPase activation / Guanine-nucleotide releasing factor / SIGNALING PROTEIN-MEMBRANE PROTEIN complex

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