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-Structure paper
Title | Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily. |
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Journal, issue, pages | Cell(Cambridge,Mass. ), Vol. 145, Page 198-211, Year 2011 |
Publish date | Jan 6, 2011 (structure data deposition date) |
Authors | Tsutakawa, S.E. / Classen, S. / Chapados, B.R. / Arvai, A.S. / Finger, L.D. / Guenther, G. / Tomlinson, C.G. / Thompson, P. / Sarker, A.H. / Shen, B. ...Tsutakawa, S.E. / Classen, S. / Chapados, B.R. / Arvai, A.S. / Finger, L.D. / Guenther, G. / Tomlinson, C.G. / Thompson, P. / Sarker, A.H. / Shen, B. / Cooper, P.K. / Grasby, J.A. / Tainer, J.A. |
External links | Cell(Cambridge,Mass. ) / PubMed:21496641 |
Methods | X-ray diffraction |
Resolution | 2.2001 - 2.6 Å |
Structure data | PDB-3q8k: PDB-3q8l: PDB-3q8m: |
Chemicals | ChemComp-SM: ChemComp-K: ChemComp-OH: ChemComp-HOH: ChemComp-SO4: |
Source |
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Keywords | HYDROLASE/DNA / helix-3 turn-helix / hydrophobic wedge / 3' flap binding site / hydrolase-DNA complex / DNA repair / replication / flap endonuclease / FEN / FEN1 / DNA / nuclease / 5' flap / ss-dsDNA junction / helix-2 turn-helix / H2TH / H3TH / divalent cation / helical gateway / cap / acid block / two metal mechanism / unpaired / 5' nuclease / human / long patch base excision repair / metal helical gateway |