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TitleInterception of Teicoplanin Oxidation Intermediates Yields New Antimicrobial Scaffolds
Journal, issue, pagesNat. Chem. Biol., Vol. 7, Page 304-, Year 2011
Publish dateMar 27, 2009 (structure data deposition date)
AuthorsLiu, Y.-C. / Li, Y.-S. / Lyu, S.-Y. / Hsu, L.-J. / Chen, Y.-H. / Huang, Y.-T. / Chan, H.-C. / Huang, C.-J. / Chen, G.-H. / Chou, C.-C. ...Liu, Y.-C. / Li, Y.-S. / Lyu, S.-Y. / Hsu, L.-J. / Chen, Y.-H. / Huang, Y.-T. / Chan, H.-C. / Huang, C.-J. / Chen, G.-H. / Chou, C.-C. / Tsai, M.-D. / Li, T.-L.
External linksNat. Chem. Biol. / PubMed:21478878
MethodsX-ray diffraction
Resolution1.93 - 3.21 Å
Structure data

PDB-2wdw:
The Native Crystal Structure of the Primary Hexose Oxidase (Dbv29) in Antibiotic A40926 Biosynthesis
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

PDB-5awv:
Crystal structure of glycopeptide hexose oxidase DBV29 complexed with teicoplanin
Method: X-RAY DIFFRACTION / Resolution: 1.93 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-HOH:
WATER

ChemComp-CIT:
CITRIC ACID

ChemComp-T55:
8-METHYLNONANOIC ACID

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-N1L:
2-amino-2-deoxy-beta-D-glucopyranuronic acid

Source
  • nonomuraea sp. atcc 39727 (bacteria)
  • actinoplanes teichomyceticus (bacteria)
KeywordsOXIDOREDUCTASE / FAD / FLAVOPROTEIN / HEXOSE OXIDASE / OXIDOREDUCTASE/ANTIBIOTIC / Oxidoreductase-antibiotic complex

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