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-Structure paper
Title | Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design |
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Journal, issue, pages | J. Biol. Chem., Vol. 286, Page 16197-16207, Year 2011 |
Publish date | Oct 28, 2010 (structure data deposition date) |
Authors | Reichau, S. / Jiao, W. / Walker, S.R. / Hutton, R.D. / Baker, E.N. / Parker, E.J. |
External links | J. Biol. Chem. / PubMed:21454647 |
Methods | X-ray diffraction |
Resolution | 2.35 Å |
Structure data | PDB-3pfp: |
Chemicals | ChemComp-MN: ChemComp-035: ChemComp-036: ChemComp-CL: ChemComp-SO4: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Shikimate pathway / Mycobacterium tuberculosis / DAH7P synthase / Aromatic biosynthesis / TIM barrel / TRANSFERASE-TRANSFERASE INHIBITOR complex |