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-Structure paper
Title | Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket. |
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Journal, issue, pages | J. Med. Chem., Vol. 54, Page 2727-2737, Year 2011 |
Publish date | Feb 9, 2011 (structure data deposition date) |
Authors | Das, K. / Bauman, J.D. / Rim, A.S. / Dharia, C. / Clark, A.D. / Camarasa, M.J. / Balzarini, J. / Arnold, E. |
External links | J. Med. Chem. / PubMed:21446702 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-3qo9: |
Chemicals | ChemComp-QO9: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / HYDROLASE/INHIBITOR / AIDS / HIV / RNA-BINDING / RNA-DIRECTED DNA POLYMERASE / VIRAL NUCLEOPROTEIN / nonnucleoside / NNRTI / HYDROLASE / HYDROLASE-INHIBITOR complex |