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TitlePyrrolidine-pyrazole ureas as potent and selective inhibitors of 11beta-hydroxysteroid-dehydrogenase type 1.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 2244-2251, Year 2011
Publish dateFeb 16, 2011 (structure data deposition date)
AuthorsVenier, O. / Pascal, C. / Braun, A. / Namane, C. / Mougenot, P. / Crespin, O. / Pacquet, F. / Mougenot, C. / Monseau, C. / Onofri, B. ...Venier, O. / Pascal, C. / Braun, A. / Namane, C. / Mougenot, P. / Crespin, O. / Pacquet, F. / Mougenot, C. / Monseau, C. / Onofri, B. / Dadji-Faihun, R. / Leger, C. / Ben-Hassine, M. / Van-Pham, T. / Ragot, J.L. / Philippo, C. / Gussregen, S. / Engel, C. / Farjot, G. / Noah, L. / Maniani, K. / Nicolai, E.
External linksBioorg. Med. Chem. Lett. / PubMed:21439819
MethodsX-ray diffraction
Resolution2.72 Å
Structure data

PDB-3qqp:
Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

Chemicals

ChemComp-S05:
3,4-dihydroquinolin-1(2H)-yl[4-(1H-imidazol-5-yl)piperidin-1-yl]methanone

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / 11BETA / HYDROXYSTEROID / DEHYDROGENASE / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

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