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TitleDiscovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 21, Page 2394-2399, Year 2011
Publish dateFeb 16, 2011 (structure data deposition date)
AuthorsBuchanan, J.L. / Newcomb, J.R. / Carney, D.P. / Chaffee, S.C. / Chai, L. / Cupples, R. / Epstein, L.F. / Gallant, P. / Gu, Y. / Harmange, J.C. ...Buchanan, J.L. / Newcomb, J.R. / Carney, D.P. / Chaffee, S.C. / Chai, L. / Cupples, R. / Epstein, L.F. / Gallant, P. / Gu, Y. / Harmange, J.C. / Hodge, K. / Houk, B.E. / Huang, X. / Jona, J. / Joseph, S. / Jun, H.T. / Kumar, R. / Li, C. / Lu, J. / Menges, T. / Morrison, M.J. / Novak, P.M. / van der Plas, S. / Radinsky, R. / Rose, P.E. / Sawant, S. / Sun, J.R. / Surapaneni, S. / Turci, S.M. / Xu, K. / Yanez, E. / Zhao, H. / Zhu, X.
External linksBioorg. Med. Chem. Lett. / PubMed:21414779
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-3qqu:
Cocrystal structure of unphosphorylated igf with pyrimidine 8
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-01P:
N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / igf / kinase / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex

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