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-Structure paper
Title | NMR structures of apo L.casei dihydrofolate reductase and its complexes with trimethoprim and NADPH. Contributions to positive cooperative binding from ligand-induced refolding, conformational changes and interligand hydrophobic interactions |
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Journal, issue, pages | Biochemistry, Year 2011 |
Publish date | Jul 11, 2006 (structure data deposition date) |
![]() | Feeney, J. / Birdsall, B. / Kovalevskaya, N.V. / Smurnyy, Y.D. / Navarro-Peran, E.M. / Polshakov, V.I. |
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Methods | NMR (solution) |
Structure data | ![]() PDB-2hm9: ![]() PDB-2l28: ![]() PDB-2lf1: |
Chemicals | ![]() ChemComp-TRR: ![]() ChemComp-NDP: |
Source |
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![]() | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Oxidoreductase / DHFR / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex / antifolates / co-operative binding / positive cooperativity / protein-ligand interactions |