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-Structure paper
Title | Discovery and SAR of spirochromane Akt inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 2410-2414, Year 2011 |
Publish date | Feb 1, 2011 (structure data deposition date) |
Authors | Kallan, N.C. / Spencer, K.L. / Blake, J.F. / Xu, R. / Heizer, J. / Bencsik, J.R. / Mitchell, I.S. / Gloor, S.L. / Martinson, M. / Risom, T. ...Kallan, N.C. / Spencer, K.L. / Blake, J.F. / Xu, R. / Heizer, J. / Bencsik, J.R. / Mitchell, I.S. / Gloor, S.L. / Martinson, M. / Risom, T. / Gross, S.D. / Morales, T.H. / Wu, W.I. / Vigers, G.P. / Brandhuber, B.J. / Skelton, N.J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21392984 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.3 Å |
Structure data | PDB-3qkk: PDB-3qkl: |
Chemicals | ChemComp-SMH: ChemComp-HOH: ChemComp-SMR: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase Domain / TRANSFERASE-TRANSFERASE INHIBITOR complex |