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Structure paper

TitleThe replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1.
Journal, issue, pagesJ. Biol. Chem., Vol. 286, Page 15344-15351, Year 2011
Publish dateSep 30, 2008 (structure data deposition date)
AuthorsSyeda, F. / Fagan, R.L. / Wean, M. / Avvakumov, G.V. / Walker, J.R. / Xue, S. / Dhe-Paganon, S. / Brenner, C.
External linksJ. Biol. Chem. / PubMed:21389349
MethodsX-ray diffraction
Resolution2.31 Å
Structure data

PDB-3epz:
Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / WINGED HELIX DOMAIN / SH3-LIKE BARREL / CELL CYCLE / METAL BINDING / DNA BINDING / DNA REPLICATION / TRANSCRIPTIONAL SILENCING / CHROMATIN / PHOSPHORYLATION / TRANSCRIPTION / TRANSCRIPTION REGULATION / EPIGENETICS ZINC / ZINC-FINGER / Methyltransferase / Nucleus / Phosphoprotein / Repressor / S-adenosyl-L-methionine / STRUCTURAL GENOMICS / STRUCTURAL GENOMICS CONSORTIUM / SGC

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