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TitleQuinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Journal, issue, pagesJ. Med. Chem., Vol. 54, Page 1914-1926, Year 2011
Publish dateJan 31, 2011 (structure data deposition date)
AuthorsSleebs, B.E. / Czabotar, P.E. / Fairbrother, W.J. / Fairlie, W.D. / Flygare, J.A. / Huang, D.C. / Kersten, W.J. / Koehler, M.F. / Lessene, G. / Lowes, K. ...Sleebs, B.E. / Czabotar, P.E. / Fairbrother, W.J. / Fairlie, W.D. / Flygare, J.A. / Huang, D.C. / Kersten, W.J. / Koehler, M.F. / Lessene, G. / Lowes, K. / Parisot, J.P. / Smith, B.J. / Smith, M.L. / Souers, A.J. / Street, I.P. / Yang, H. / Baell, J.B.
External linksJ. Med. Chem. / PubMed:21366295
MethodsX-ray diffraction
Resolution2.02 Å
Structure data

PDB-3qkd:
Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

Chemicals

ChemComp-HI0:
(R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsAPOPTOSIS/INHIBITOR / Bcl-2 family fold / APOPTOSIS-INHIBITOR complex

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