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TitleRational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.
Journal, issue, pagesJ. Inorg. Biochem., Vol. 105, Page 509-517, Year 2010
Publish dateAug 17, 2010 (structure data deposition date)
AuthorsLi, Z. / Liu, Z. / Cho, D.W. / Zou, J. / Gong, M. / Breece, R.M. / Galkin, A. / Li, L. / Zhao, H. / Maestas, G.D. ...Li, Z. / Liu, Z. / Cho, D.W. / Zou, J. / Gong, M. / Breece, R.M. / Galkin, A. / Li, L. / Zhao, H. / Maestas, G.D. / Tierney, D.L. / Herzberg, O. / Dunaway-Mariano, D. / Mariano, P.S.
External linksJ. Inorg. Biochem. / PubMed:21333622
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3ohi:
Structure of Giardia fructose-1,6-biphosphate aldolase in complex with 3-hydroxy-2-pyridone
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HDX:
({3-hydroxy-2-oxo-4-[2-(phosphonooxy)ethyl]pyridin-1(2H)-yl}methyl)phosphonic acid

ChemComp-HOH:
WATER

Source
  • giardia intestinalis (eukaryote)
KeywordsLYASE / Class II fructose-1 / 6-bisphosphate aldolase / glycolytic pathway

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