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-Structure paper
Title | Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 1315-1319, Year 2011 |
Publish date | Nov 23, 2010 (structure data deposition date) |
![]() | Dong, Q. / Dougan, D.R. / Gong, X. / Halkowycz, P. / Jin, B. / Kanouni, T. / O'Connell, S.M. / Scorah, N. / Shi, L. / Wallace, M.B. / Zhou, F. |
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Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | ![]() PDB-3pp1: |
Chemicals | ![]() ChemComp-ATP: ![]() ChemComp-MG: ![]() ChemComp-IZG: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase domain / Kinase / ATP binding / TRANSFERASE-TRANSFERASE INHIBITOR complex |