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Structure paper

TitleUnique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 3210-3215, Year 2011
Publish dateJan 6, 2011 (structure data deposition date)
AuthorsKirouac, K.N. / Ling, H.
External linksProc. Natl. Acad. Sci. USA / PubMed:21300901
MethodsX-ray diffraction
Resolution1.95 - 2.45 Å
Structure data

PDB-3q8p:
Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-3q8q:
Human DNA polymerase iota incorporating dATP opposite 8-oxo-guanine
Method: X-RAY DIFFRACTION / Resolution: 2.031 Å

PDB-3q8r:
Human DNA polymerase iota incorporating dGTP opposite 8-oxo-guanine
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

Source
  • homo sapiens (human)
KeywordsTransferase/DNA / DNA polymerase / Transferase-DNA complex

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