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Structure paper

TitleStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
Journal, issue, pagesEmbo J., Vol. 30, Page 1137-1148, Year 2011
Publish dateJul 29, 2010 (structure data deposition date)
AuthorsYin, Y. / Li, Y. / Kerzic, M.C. / Martin, R. / Mariuzza, R.A.
External linksEmbo J. / PubMed:21297580
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-3o6f:
Crystal structure of a human autoimmune TCR MS2-3C8 bound to MHC class II self-ligand MBP/HLA-DR4
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Autoimmunity / Multiple sclerosis / T cell receptor / HLA class II / protein-protein complex / Immunoglobulin fold / Membrane

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