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-Structure paper
Title | Design and synthesis of potent Gram-negative specific LpxC inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 1155-1161, Year 2011 |
Publish date | Oct 12, 2010 (structure data deposition date) |
Authors | Faruk Mansoor, U. / Vitharana, D. / Reddy, P.A. / Daubaras, D.L. / McNicholas, P. / Orth, P. / Black, T. / Arshad Siddiqui, M. |
External links | Bioorg. Med. Chem. Lett. / PubMed:21273067 |
Methods | X-ray diffraction |
Resolution | 1.93 Å |
Structure data | PDB-3p76: |
Chemicals | ChemComp-IMD: ChemComp-P76: ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Amidohydrolases / Amino Acid Motifs / Binding Sites / Drug Design / Enzyme Inhibitors / Escherichia coli Proteins / Hydrophobicity / Lipid A / Protein Conformation / Protein Folding / Recombinant Fusion Proteins / Structure-Activity Relationship |