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TitleStructure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 108, Page 2396-2401, Year 2011
Publish dateJan 4, 2011 (structure data deposition date)
AuthorsHastie, K.M. / Kimberlin, C.R. / Zandonatti, M.A. / Macrae, I.J. / Saphire, E.O.
External linksProc. Natl. Acad. Sci. USA / PubMed:21262835
MethodsX-ray diffraction
Resolution1.5 - 2 Å
Structure data

PDB-3q7b:
Exonuclease domain of Lassa virus nucleoprotein
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3q7c:
Exonuclease domain of Lassa virus nucleoprotein bound to manganese
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

Source
  • lassa virus
KeywordsHYDROLASE / DEDDh exonuclease / 3' exonuclease / dsRNA exonuclease / arenavirus nucleoprotein

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