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Structure paper

TitleFactor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
Journal, issue, pagesFEBS J., Vol. 278, Page 1086-1097, Year 2011
Publish dateDec 2, 2010 (structure data deposition date)
AuthorsYang, M. / Chowdhury, R. / Ge, W. / Hamed, R.B. / McDonough, M.A. / Claridge, T.D. / Kessler, B.M. / Cockman, M.E. / Ratcliffe, P.J. / Schofield, C.J.
External linksFEBS J. / PubMed:21251231
MethodsX-ray diffraction
Resolution2.28 Å
Structure data

PDB-2y0i:
FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE/PEPTIDE / OXIDOREDUCTASE-PEPTIDE COMPLEX / DIOXYGENASE / HELIX-LOOP-HELIX-BETA / FACIAL TRIAD / ASPARAGINYL/ASPARTYL HYDROXYLASE / ANKYRIN REPEAT DOMAIN

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