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Structure paper

TitleX-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Journal, issue, pagesNature, Vol. 469, Page 428-431, Year 2011
Publish dateOct 7, 2010 (structure data deposition date)
AuthorsNury, H. / Van Renterghem, C. / Weng, Y. / Tran, A. / Baaden, M. / Dufresne, V. / Changeux, J.P. / Sonner, J.M. / Delarue, M. / Corringer, P.J.
External linksNature / PubMed:21248852
MethodsX-ray diffraction
Resolution3.2 - 3.3 Å
Structure data

PDB-3p4w:
Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-3p50:
Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-LMT:
DODECYL-BETA-D-MALTOSIDE / detergent*YM

ChemComp-DSF:
(2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane

ChemComp-PLC:
DIUNDECYL PHOSPHATIDYL CHOLINE / phospholipid*YM

ChemComp-HOH:
WATER

ChemComp-PFL:
2,6-BIS(1-METHYLETHYL)PHENOL

Source
  • gloeobacter violaceus (bacteria)
KeywordsMEMBRANE PROTEIN / TRANSPORT PROTEIN / transmembrane helices / ligand-gated ion channel

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