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TitleConstraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
Journal, issue, pagesJ. Mol. Biol., Vol. 407, Page 138-148, Year 2011
Publish dateOct 12, 2009 (structure data deposition date)
AuthorsOyen, D. / Srinivasan, V. / Steyaert, J. / Barlow, J.N.
External linksJ. Mol. Biol. / PubMed:21238460
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-3k74:
Disruption of protein dynamics by an allosteric effector antibody
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • escherichia coli k-12 (bacteria)
  • lama glama (llama)
KeywordsOXIDOREDUCTASE / Immunoglobulin / protein-nanobody complex / Antibiotic resistance / Methotrexate resistance / NADP / One-carbon metabolism / Trimethoprim resistance

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