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Structure paper

TitleStructures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Journal, issue, pagesProtein Cell, Vol. 1, Page 491-500, Year 2010
Publish dateMay 26, 2010 (structure data deposition date)
AuthorsWu, Y. / Lou, Z. / Miao, Y. / Yu, Y. / Dong, H. / Peng, W. / Bartlam, M. / Li, X. / Rao, Z.
External linksProtein Cell / PubMed:21203964
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-3n6l:
The crystal structure of RNA-dependent RNA polymerase of EV71 virus
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3n6m:
Crystal structure of EV71 RdRp in complex with GTP
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3n6n:
crystal structure of EV71 RdRp in complex with Br-UTP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-BUP:
5-bromouridine 5'-(tetrahydrogen triphosphate)

Source
  • human enterovirus 71
KeywordsTRANSFERASE / EV71 / RdRp / GTP / Br-UTP

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