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TitleA highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
Journal, issue, pagesJ. Exp. Med., Vol. 208, Page 91-102, Year 2011
Publish dateNov 13, 2010 (structure data deposition date)
AuthorsSethi, D.K. / Schubert, D.A. / Anders, A.K. / Heroux, A. / Bonsor, D.A. / Thomas, C.P. / Sundberg, E.J. / Pyrdol, J. / Wucherpfennig, K.W.
External linksJ. Exp. Med. / PubMed:21199956
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-3pl6:
Structure of Autoimmune TCR Hy.1B11 in complex with HLA-DQ1 and MBP 85-99
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TCR-MHC complex / Immunoglobulin fold / Immune receptor / Membrane

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